Books

Available in hardback, paperback and Kindle from Amazon.

Although there are numerous books on drug metabolism, Radiotracers in Drug Development is unique in explaining how radiotracers are used to elucidate a drug’s absorption, distribution, metabolism, and excretion (ADME). Covering traditional and recent technologies and applications, the book takes a strong industrial approach, discussing the basics of scintillation counting and untangling the various data processing methods often specific to individual manufacturers.

A unique reference and training aid essential for every drug metabolism department or drug metabolism research team, the book provides insight into the use and practice of ADME in a way that is both instructive and practical. Moving easily across the boundaries of biology, chemistry, and physics, this is the only comprehensive, interdisciplinary resource covering the how-tos of employing radiotracers in drug development. It provides detailed information on how the science is relevant to the registration process.

Identical Outsides, Different Insides

(How isotopes have shaped science for a hundred years)

A putative Popular Science book

The periodic table and the atom are common themes of popular science but the story of how isotopes have shaped our lives over the last century has been largely overlooked. There are 92 naturally occurring elements in the periodic table but hidden underneath there are around 4,000 isotopes, rarely seen, often ignored, and the subject of this book.

Isotopes are separated only by their atomic mass, which prompted their discoverer Frederick Soddy to say, “put colloquially, their atoms have identical outsides but different insides,” which is where this book gets its title. Although we have known of isotopes for little more than 100-years, we use them today in all fields of scientific endeavour, from archeology to biochemistry, from ecology to geology, from medicine to anthropology. This book takes a journey through the isotopes, often recounting from the author’s own 30-years’ experience, to tell fascinating stories of what they tell us about the natural world. Through isotopes we know the solar system is 4.5 billion years old, that water moved on Mars just 80-million years ago and an asteroid hit our planet, wiping out the dinosaurs, 66-million years ago. Those same isotopes have told us such diverse things as how photosynthesis works, how our body ages and handles everyday toxins and how we can peer uninvasively inside the brain. Isotopes help untangle complex food webs, track down drug traffickers, ivory poachers and murders, and trace movement of animals and humankind across the planet. They also leave no doubt carbon from burning fossil fuels is warming our climate.

Virtually no part of our modern understanding of nature is untouched by isotope science, yet it’s a story seldom told – Identical Outsides, Different Insides intends to put that right.

Pharmacokinetics from the beginning

(Planned to be a self-published textbook to make it available on a student budget)

By Graham Lappin & Mark Seymour

There are many textbooks on pharmacokinetics and so why yet another? The majority of textbooks cover the theory and mathematics of pharmacokinetics, but few start from the very beginning – the basic time versus drug-concentration data. The book is written as if the reader had just completed a pharmacokinetic study and was presented with tables of data which needed to be processed for publication. It is essentially a do-it-yourself workshop in real-world pharmacokinetics, which you can follow through step-by-step. The principal pharmacokinetic parameters are calculated from tables of data with nothing more than a pencil, graph-paper and calculator. Of course, these days, there are computer programs to do this for you, taking much less time and hassle, so why would you want to do the calculations manually? The answer is two-fold. Many of the pharmacokinetic computer programs are expensive and are primarily aimed at industry where many thousands of data points are acquired. For the less resourced student or university, it may be necessary to compile your own spreadsheets in order to conduct the calculations. This book will lead the way to that objective.

Pharmacokinetics from the beginning is based upon a series of YouTube videos which are linked on the homepage.