Pharmablogology

A sober look at dexamethasone

A Covid-19 blog post for the non-expert It stared with a 16th June 2020 press release from the University of Oxford “Low-cost dexamethasone reduce death by up to one third in hospitalised patients with severe respiratory complications of COVID-19” – which triggered the equivalent of a media cytokine storm (pun explained shortly). I do not want,Continue reading “A sober look at dexamethasone”

Has the scientific method been suspended?

There’s a scene in the Netflix series Space Force when Chief Scientist Dr. Adrian Mallory asks, “why do you distrust scientists?” To which General Naird angrily replies, “you scientists say don’t eat carbs one day and only eat carbs the next”. One of the scientists in the room interjects, saying, “because of the sample sizesContinue reading “Has the scientific method been suspended?”

Broken Clock Fallacy

I had a terrible bout of flu in November. In fact, my wife said she’d never known me so ill. I had a fever that went up and down, aching joints, a prolonged dry cough and found it hard to breath when laying down at night. I have an oxometer which occasionally dipped below 90%Continue reading “Broken Clock Fallacy”

A scientific tightrope

The two most senior scientific advisors to the UK, Sir Patrick Vallance (Chief Scientific Advisor) and Professor Chris Whitty (Chief Medical Officer) have come into a lot of criticism recently for failing to say what they really believe regarding the Government’s response to the Covid-19 outbreak. As Civil Servants they are meant to be impartialContinue reading “A scientific tightrope”

Is Covid-19 over… no it’s not!

In this blog I try to keep to the science I know, and If I don’t have enough expertise, I reach out to those who do. I declare therefore, I am wandering into fresh territory in this post and, at least in part, it’s my opinion – although I believe backed up with the facts.Continue reading “Is Covid-19 over… no it’s not!”

Covid-19 vaccine pessimism

Another blog on Covid-19 for the non-expert I’ve seen claims on social media and in the press saying a vaccine for Covid-19 may never arrive. The Telegraph, and The Guardian are two examples. The three most commonly quoted reasons I’ve seen for vaccine pessimism are: (1) vaccines take many years to make, the mumps vaccineContinue reading “Covid-19 vaccine pessimism”

Covid-19 – warnings ignored

I’ve heard it said, we have not experienced a pandemic since the Spanish flu of 1918 so how could anyone predict Covid-19? Just about everything in that statement is wrong. Everyone has heard of Spanish flu, but how many have heard of the 1957 flu pandemic, or the one in 1968? We see an annualContinue reading “Covid-19 – warnings ignored”

What is Remdesivir and how does it work?

Another Covid-19 blog post for the non-expert. Parts of the media are claiming a drug called remdesivir has arrived to save us The BBC: “Remdesivir: Drug has ‘clear-cut’ power to fight coronavirus” RFI – Radio France Internationale, live news: “US claims major breakthrough after positive trial of coronavirus drug remdesivir” The Express: “Hope of coronavirusContinue reading “What is Remdesivir and how does it work?”

I just know I'm right

Apart from death and taxes, the next most certain thing in life is how social media will suddenly light up with self-proclaimed experts on whatever topic grasps the public interest at the time. Over the past few years we’ve had upsurges in confident opinion on everything from economics, British constitutional law, international trade, vaccines andContinue reading “I just know I'm right”

Covid-19 and blood pressure

As well as a vaccine, studies are being conducted into drugs which might stop, or at least inhibit, the effects of the SARS-CoV-2 virus. Modern drugs are designed to target specific sites, called receptors, in the body and the right choice of receptor is often the difference between a successful drug and a dud. IContinue reading “Covid-19 and blood pressure”