Inside a 5MV Accelerator
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For archived posts, click on “by Pharmablogolgy”
Spinal muscular atrophy and Zolgensma
Reports have appeared in the UK media of the NHS administering the most expensive drug in the world to a 5-month-old boy. Onasemnogene abeparvovec (sold as Zolgensma), costing around two and a half million US-dollars (£1.79 million),* is a gene therapy agent to treat spinal muscular atrophy. The headlines quoted the price but gave scantContinue reading “Spinal muscular atrophy and Zolgensma”
A Crisis of Infection
It’s amazing what humankind can achieve with the right amount of political will and resources. After the attack on Pearl Harbor in December 1941, Roosevelt oversaw the rebuilding of the Pacific fleet in only 6-months. Driven by rivalry with the Soviet Union, Kennedy announced in May 1961, “…we choose to go to the moon …”Continue reading “A Crisis of Infection”
Magic mushrooms and depression
Recent trials have suggested the active ingredient of magic mushrooms, psilocybin, might be a treatment for depression. This might be linked to widely used antidepressants such as Prozac.
What has opioid addiction got to do with cats?
Cat lovers will know the effect of catnip on their beloved pets only too well. Catnip (Nepeta cataria) is a member of the mint family and along with a similar plant called silver vine (Actinidia polygamy) it elicits a feline euphoria followed by a period of placid tranquillity, lasting perhaps 15-30 minutes. The effects wereContinue reading “What has opioid addiction got to do with cats?”
Maradona and a Biochemist
I start this blog post with, “I don’t want to sound bitter but…” and then I’ll go on to probably do just that. The media is full of tributes to Diego Maradona; some call him a genius, some a deeply flawed legend. For me personally, he was a cocaine addict connected to the Mafia whoContinue reading “Maradona and a Biochemist”
Pfizer-BioNTech are making a mRNA vaccine, but what is that?
Covid-19 blog for the non-expert The Pfizer-BioNTech vaccine for Covid-19 is all over the media. What hasn’t been in the headlines so much, is that this is a mRNA vaccine and if successful, it’ll be the first of its type. Some say they will not take it because it’s “rushed” but this misses the pointContinue reading “Pfizer-BioNTech are making a mRNA vaccine, but what is that?”
90% effective Covid-19 vaccine
The headlines are jubilant with “Covid-19” vaccine 90% effective. As one of those skeptical scientists, I’m in a difficult position because I don’t want to dampen any hope, but at the same time it’s worth questioning the headline to see what’s really behind it. The announcement was from Pfizer and BioNTech, and the media areContinue reading “90% effective Covid-19 vaccine”
New Covid-19 tests
A Covid-19 blog post for the non-expert We’ve been hearing how the UK government wants to return to normal life under its £100bn Operation Moonshot Covid-19 testing programme. Headlines such as those in the Daily Mail have proclaimed “Prospect’ of 10-minute ‘rapid turnaround’ Covid tests” but others including the BMJ are not so sure. I thought,Continue reading “New Covid-19 tests”
Atomic Butterflies
When I first moved to my current house some 20-years ago, my next-door neighbour had a buddleia growing in their garden which overhung part of my driveway. In the summer, the shrub was a resting spot for a multitude of red admiral butterflies, which exploded into a swarm if I got too close. Sadly, thatContinue reading “Atomic Butterflies”
Death by Liquorice
A blog post for the non-expert The media is reporting a 54-year-old construction worker from Massachusetts has died of liquorice poisoning. Not for the first time when dealing with such issues, the press reports are so similar that they were likely all cloned from the original source, a paper in the New England Journal of Medicine.Continue reading “Death by Liquorice”
Serial killers are no joke
For those of you reading this in the UK, you may have seen the three-part drama on ITV called Des, which followed the serial killing career of Dennis Nilsen. An horrific and macabre story and yet somehow frighteningly captivating. As scary as serial killers are, they represent a minuscule proportion of the population and soContinue reading “Serial killers are no joke”
Cannabis tyres
I started my post-graduate scientific career as a plant biochemist (phytochemist to be more precise). Once talking to a geologist about how fascinating plants are, he replied, “plants just get in the way of the rocks,” and so I guess your interests very much depend on your viewpoint. I moved up the career evolutionary treeContinue reading “Cannabis tyres”
Ammonium nitrate: a Jekyll and Hyde chemical
Please donate to the appeal if you can, as hospitals are reporting they are unable to treat further casualties as hundreds of beds immediately filled up following the blast. __________________________________________________________________________________________ The explosion which rocked Beirut’s Port was almost certainly caused by inappropriate storage of 2,750 tons of ammonium nitrate. But what is ammonium nitrate and whyContinue reading “Ammonium nitrate: a Jekyll and Hyde chemical”
What is interferon and is it effective against Covid-19?
A blog post for the non-expert Our best hope against Covid-19 is an effective vaccine, and efforts in that direction are galloping along like no other time in history. There are so many vaccines being investigated, it’s hard to keep up with the numbers, but at the time of writing there appear to be wellContinue reading “What is interferon and is it effective against Covid-19?”
Covid-19 was genetically-engineered
A Covid-19 blog post for the non-expert The story that Covid-19 is a genetically-engineered virus from a Wuhan laboratory has gone viral across the internet (dated pun intended). President Trump implied it, and the Daily Express ran a 10th March headline, “Coronavirus may have been genetically engineered for the efficient spreading in the human population,Continue reading “Covid-19 was genetically-engineered”
Murder and Atoms
Richard Hill and fellow hikers were walking in the Yorkshire Dales, about an hour’s drive from where I live, when they stopped to take a photograph. He stood by a stream near to the Sell Gill Holes caves in Pen-y-ghent but didn’t notice, just behind him, was the face-down body of a half-naked woman. TheyContinue reading “Murder and Atoms”
Education through adversity
A different sort of pandemic blog post, and a rather personal one. There are problems reopening schools, universities are going virtual and post-graduates are struggling to complete. Education is having a hard time, and many students are rightly concerned about the impact this will have on their careers. If I was in this situation, I’dContinue reading “Education through adversity”
A sober look at dexamethasone
A Covid-19 blog post for the non-expert It stared with a 16th June 2020 press release from the University of Oxford “Low-cost dexamethasone reduce death by up to one third in hospitalised patients with severe respiratory complications of COVID-19” – which triggered the equivalent of a media cytokine storm (pun explained shortly). I do not want,Continue reading “A sober look at dexamethasone”
Has the scientific method been suspended?
There’s a scene in the Netflix series Space Force when Chief Scientist Dr. Adrian Mallory asks, “why do you distrust scientists?” To which General Naird angrily replies, “you scientists say don’t eat carbs one day and only eat carbs the next”. One of the scientists in the room interjects, saying, “because of the sample sizesContinue reading “Has the scientific method been suspended?”
Broken Clock Fallacy
I had a terrible bout of flu in November. In fact, my wife said she’d never known me so ill. I had a fever that went up and down, aching joints, a prolonged dry cough and found it hard to breath when laying down at night. I have an oxometer which occasionally dipped below 90%Continue reading “Broken Clock Fallacy”
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Graham Lappin 